Be Careful With My Heart is about the story of Maya Dela Rosa (Jodi Sta. Maria), a simple girl from the province San Nicolas who are introduced as tour guides including her older sister, Cristina Rose “Kute” Dela Rosa (Aiza Seguerra) and Nephew, Pocholo “Cho” Macavinta (JM Ibanez). With lack of money for their daily expenses and household repairs, Maya and Kute are having a hard time reaching their dreams to become a Flight Stewardess and a sea worker. On a rainy night, Kute accidentally fell off after she tried to fix their roof which disappointed Kute to achieve her dream of becoming a sea woman. With large medical bills, Maya became interested in working abroad for two years to help her family financially. Unfortunately, Maya became a victim of a swindler employer. Despite of being unfortunate, Maya still hoped to become a Flight Stewardess with the help of Richard “Sir Chef/Ricardo” Lim (Richard Yap) who offered her a work as a nanny to his daugher, Abigail Ruth “Abby” Lim (Mutya Orquia). Without any second thoughts, Maya accepted Richard’s offer, since Maya knows that Richard is her last hope because of his influence in the airline industry. With this in mind, will Maya ever achieve her dreams as a Flight Stewardess even though she started as a nanny to Abby?